基于FBG 测温的肿瘤裸鼠激光热疗实验

　　陈娜，陈少锋，朱鸿飞，刘书朋，陈振宜

　　基金项目：教育部博士点新教师基金项目(20093108120017)

　　作者简介：陈娜，(1982-)，女，副教授，主要研究方向：光纤传感.

　　(上海大学，特种光纤及光接入网省部共建重点实验室，上海 200072)

　　摘要：本文将光纤布拉格光栅作为完全分布式温度传感器，应用在肿瘤裸鼠动物模型的激光热疗实验中，构建了一套带有实时温度监控的热疗系统。该系统能够实时获取光纤布拉格光栅的反射谱，通过反演程序计算，得到沿光栅轴向的温度场分布，再反馈控制输入激光的功率大小，将肿瘤边界的温度始终维持在设定的温度。实验结果表明，经过激光热疗后，有效抑制了实验裸鼠的肿瘤生长。

　　关键词：温度传感;光纤布拉格光栅;激光热疗;完全分布式测量;动物模型;在体实验

　　中图分类号：TN249

　　Laser thermotherapy experiments on nude mice tumor model with FBG temperature measurement

　　Chen Na, Chen Shaofeng, Zhu Hongfei, Liu Shupeng, Chen Zhenyi

　　(The Key Laboratory of Specialty Fiber Optics and Optical Access Networks, Shanghai University,ShangHai 200072)

　　Abstract: In this paper, fiber Bragg grating (FBG) is used as a fully distributed temperature sensor in laser thermotherapy. We bult a thermotherapy system with temperature measurement and control. This system can measure the FBG axial temperature distribution accurately by aquiring FBG reflection spectra in real time and calculating with spectra inversion program. With this

　　feedback, control temperature of tumor boundary at a certain value can be realized by varying power of laser. The experimental results show that after laser thermotherapy, the growth of tumors in nude mice have been inhibited effectively.

　　Keywords: temperature sensing; fiber Bragg grating; laser thermotherapy; fully distributed measurement; animal model; in vivo experiment