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微结构对口腔微生物粘附的影响

  微结构对口腔微生物粘附的影响

  包崇云,肖宇

  (口腔疾病研究国家重点实验室,华西口腔医学院,四川大学,成都,610041)

  摘要:研究表明,材料表面的微形貌影响着细胞以及微生物的粘附、增殖分化等行为,在本文的工作中,我们在纳米羟基磷灰石上制备了不同形状以及尺寸的微结构,并以石墨粉作为参照对比细菌的粘附行为。结果表明白色念珠菌(C.a) 倾向于粘附在尺寸为5微米的微结构上,同时石墨粉则倾向于10微米以及20微米的微结构。变形链球菌(S.m)的粘附则基本不受材料微结构形态以及尺寸的影响。但是,其增值行为受到了微结构的抑制作用。

  关键词:口腔基础医学;微结构;口腔细菌;羟基磷灰石;

  中图分类号:R318

  Effect of micro-structure on the bio-adhesion of oral bacteria

  Bao Chongyun, Xiao Yu

  (State Key Laboratory of Oral Diseases, West China School of Stomatology, Sichuan University, Chengdu ,610041)

  Foundations: Natural Science Foundation of China (No. 81371181, No. 81171005), Ministry of Education,Fund for the Doctoral (No. 20100181110058) Brief author introduction:Bao Chongyun (1967-),Male, Professor. His main research area is in bone tissue engneering.

  Abstract: Ihe micro-morphology of local micro-environment affects the adhesion, proliferation, differentiation and other acts of cells and microorganisms. To compare the adsorptive behavior of graphite powder and adhesive behavior of microbe on micro-structures, we prepared micro-structures on hydroxyapatite (HA) with different sizes and shapes. The results showed that Candida albicans was mostly prone to adhere onto 5 μm micro-structures, while 10-20 μm graphite powder was mostly prone onto adsorb to 10 μm and 20 μm micro-structures. The adhesion of Streptococcus mutans which grew in a chain was almost not affected by the size or shape of micro-structures, however, its proliferation was obstructed by micro-structures.

  Key words: Basic Science of Stomatology;Micro-structure; Oral Bacteria; Hydroxyapatite;

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